Target Organ Toxicity Series I – The Liver & Kidneys – NO MORE BOOKINGS TAKEN. NEW DATES TO BE SCHEDULED FOR 2024

PART I – Target organ toxicity and adverse effects

• What is meant by target organ toxicity
• The difference between adverse and non-adverse effect

PART II – The liver  as a target organ of toxicity

• The structure and functions of the liver (including its role in metabolism)
• What is meant by ‘adaptation’ and its toxicological significance
• What is meant by hepatic enzyme induction
• Why the liver is commonly a target organ for toxicity, and how it responds to chemical injury (necrosis, cirrhosis, steatosis, cholestasis and hepatocarcinogenesis) 
• The common indicators of liver injury and how they should be interpreted (e.g. decreased albumin levels, elevated alkaline phosphatase, etc)

PART III – The kidney as a target organ of toxicity

• The structure and function of the kidneys
• Filtration, re-absorption and secretion processes and their role in excretion
• Why the kidneys are a common target organ for toxicity
• The difference between acute and chronic renal failure with specific examples of chemicals which cause this type of effect 
• How to assess  renal injury/function and the interpretation of the results

• Technical/scientific staff who work in a regulatory department
• Authors of safety data sheets (SDS) and/or extended safety data sheets (eSDS)
• Staff involved in classification and labelling under EU CLP/ GHS
• Occupational hygienists
• Occupational health advisors
• Chemical risk assessment professionals

• Training handbook complementing the webinar.
• Toxicology glossary containing a handy list of essential toxicology terms for your review.
• Copy of all slides used during the training.
• Certificate of attendance (if required).